At noon on October 25th, the Transcontinental Express left Geneva Station with almost one thousand people aboard. Their destination: Basel, Paris, Brussels, Amsterdam, Copenhagen, and Stockholm. No one arrived.

A man infected with a US-made biological weapon escapes onto a train bound for Sweden – a train occupied by a famous neurologist, his author ex-wife, a Holocaust survivor, the wife of a German arms dealer, the young heroin trafficker with whom she’s having an affair, and the undercover Interpol agent pursuing him. But with the US government desperate to stop the spread of the virus as well as cover up its own scandal, the lives of everyone on board the train may need to be sacrificed.

From director George P. Cosmatos (Tombstone) and legendary producers Carlo Ponti (Doctor Zhivago) and Lord Lew Grade (The Eagle Has Landed) comes an all-star disaster movie featuring Sophia Loren, Richard Harris, Burt Lancaster, Martin Sheen, Lee Strasberg, OJ Simpson, and Ava Gardner, a thrilling score by Oscar-winning composer Jerry Goldsmith, and breathtaking images of the European vistas by cinematographer Ennio Guarnieri.